Expression of tumor-specific antigens in mouse somatic cell hybrids.

Inbred 129/Sv mice were resistant to inoculation of teratocarcinoma cells when preimmunized with (129teratocarcinoma x C3H L-cell) somatic cell hybrids ob tained by fusion with UV-inactivated Sendai virus. Re sistance of DBA/2 mice to the highly malignant L1210 leukemia was also obtained by the use of (L1210 x C3H L-cell) hybrids. That this resistance was specific was sug gested by regular takes of L1210 cell challenge in all DBA/2 mice immunized against different tumor cells un related to L1210. These experiments indicate the existence of teratocarcinomaand L1210 leukemia-specific antigens in their respective hybrids, even when hybrids do not pro duce tumors in compatible F, mice.